The announcement has been met with disappointment from Macleay Valley Taxis, with managing director Jeff Saunders telling the Argus it will impact taxi services in the shire.

"Many Uber drivers only operate during peak times when they will get the most amount of customers and money. It will impact our business and could see the number of taxis in the area decrease," he said.

"If business decreases, we could fold and then because Uber drivers don't work 24/7, people would be left without a transport service."

Macleay Valley Taxis also offers a wheelchair taxi, a service Jeff said could disappear if Uber becomes popular in the region.

"We have always made sure we offer a 24-hour service and have services fitted to everyone's needs," Jeff said.

"If this puts pressure on the business, drivers would have to be let go which means less services for the community."

Uber Australia general manager Dom Taylor said the announcement comes after the company had heard from people across the State wanting Uber to come to their community.

"We're keen to see locals and tourists alike support these regional drivers when the Uber rider app goes live state-wide in April - whether it's a regular Saturday night or visitors heading to the Slim Dusty Festival," he said.

"Our first regional city to launch was Newcastle in 2016. What we've learnt is that Uber is a great way for people to get home safely and avoid drink driving. It's also a great opportunity for people to earn some extra dollars on the weekends or during peak tourist periods.

"We believe ride share can help drive business as people get around to the fantastic restaurants, events and pubs that Kempsey has to offer."

Jeff said he is concerned Uber expanding to regional areas will see taxi services disappear.

"As disappointing as it is, in the long term it means 24-hour taxi services will no longer be around. If there are changes in the demand for taxis, we will have to cop it and scale back our services," he said.

Macleay Valley Taxis employs 15 drivers who each work three to four days per week.

From today, Wednesday March 4, locals interested in becoming Uber drivers can sign up through the app. The Uber app will be turned on for Kempsey just before the Easter long weekend in April.